• Deficiency can also occur in people who supplement with zinc without also increasing copper intake. Zinc interferes with copper absorption.Sandstead HH. Requirements and toxicity of essential trace elements, illustrated by zinc and copper. Am J Clin Nutr 1995;61(suppl):62S–4S.
• Health consequences of zinc-induced copper deficiency can be quite serious.Broun ER. Greist A, Tricot G, Hoffman R. Excessive zinc ingestion. A reversible cause of sideroblastic anemia and bone marrow depression. JAMA 1990;264:1441–3.
• In the absence of copper supplementation, vitamin C supplementation has also been reported to mildly impair copper metabolism.Jacob RA, Skala JH, Omaye ST, Turnlund JR. Effect of varying ascorbic acid intakes on copper absorption and ceruloplasmin levels of young men. J Nutr 1987;117:2109–15.
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