The Townsend Letter: Twenty-six
boys (aged 6-13 years) with attention-deficit hyperactivity disorder
(ADHD) were randomly assigned to receive, in double-blind fashion, one
of two treatment protocols: placebo-carnitine-placebo or carnitine-placebo-carnitine.
Each treatment period lasted eight weeks, for a total of 24 weeks. The
dose of L-carnitine was 100 mg per kg of body weight per day, with a
maximum of 4 g/day, taken in two divided doses after meals. Patients
were considered treatment responders if there was either 1) a 30% decrease
in the Child Behavior Checklist (CBCL; a parental rating scale) score,
compared with baseline, or a normalization of this score, or 2) a 30%
decrease in the number of "most severe" ratings on the Conners
teacher (CT)-rating scale, compared with baseline. Among the 24 boys
who completed at least two of the three treatment periods, the proportion
of responders according to the CBCL rating scale was 54% in the L-carnitine
group and 13% in the placebo group (p < 0.02). The proportion of
responders according to the CT rating scale was 50% in the L-carnitine
group and 17% in the placebo group (p < 0.05). L-Carnitine was generally
well tolerated, although one patient experienced an unpleasant body
odor. This side effect was thought to be due to the formation of trimethylamine.
The authors had previously found that the development of this body odor
could be prevented by treatment with riboflavin, but riboflavin was
not used in the present study.
of attentional factors in sport performance has been
recognised by athletes and coaches, only in recent years have researchers
begun to investigate the nature of attention-performance relationship
(Roberts et al, 1999).
• The mind boosting effect of acetylcarnitine is often noticed within a few hours, or less. Most people report feeling mentally sharper, having more focus and being more alert. Acetyl-l-carnitine may be used as an overall mind booster. Carnitine, or L-carnitine, is a naturally occurring substance found in most cells of the body, particularly the brain and neural tissues, muscles, and heart. Acetyl-l-carnitine has significantly more noticeable effect on the mind than carnitine. In addition to producing energy, these two nutrients remove toxic accumulations of fatty acids from mitochondria, keeping these organelles healthy and functioning at their best. Energy production in the mitochondria is not a perfect process and toxic metabolites can often accumulate. Adequate acetyl-l-carnitine intake can help minimize this accumulation.Dr. Ray Sahelian
Acetyl-L-carnitine is a molecule found naturally throughout the body
that helps to transport fats into the mitochondria, the tiny energy
"factories" in all living cells. ALC is closely related to
carnitine, a natural amino acid that is also available as a nutritional
supplement (ALC is considered the more potent of the two); it is also
related to choline, in both chemical structure and clinical effects.
ALC enhance cognition and stimulate creativity--it is thought
to improve communication between the right and left hemispheres of the
brain, thereby promoting intuitive and balanced thinking. Though
the action of ALC in the brain is not yet fully understood, some researchers
believe it works by helping to facilitate the activity of important
neurotransmitters such as acetylcholine and dopamine in the brain.
ALC is found in various concentrations in the brain and its
levels are significantly reduced with aging. In numerous animal
studies ALC has been shown to have the remarkable ability of improving
not only cognitive changes, but also morphological (structural) and
neurochemical changes. ALC has varied effects on cholinergic activity.F.
Maccari, A. Arseni, P. Chiodi, et al, Exp Geront 1990; 25: 127-134.
ALC also has the ability to cross into the brain where it acts as a
powerful antioxidant, preventing the deterioration of brain cells that
normally occurs with age. Because of this protective effect,
ALC may be beneficial in the prevention and treatment of free-radical
mediated diseases, such as Alzheimer's and Parkinson's disease. Puca
FM, Genco S, Specchio LM, et al. Clinical pharmacodynamics of acetyl-L-carnitine
in patients with Parkinson's disease. Int J Clin Pharmacol Res 1990;10(1-2):139-43.)
• A 1987 Italian study published in Drugs Under Experimental and Clinical Research reported on the administration of carnitine to low-spirited mature subjects for a period of two months. The participants were given either carnitine or placebo. The experimental results revealed that the benefits of carnitine were “statistically significant.” An elevation in mood was observed in those given carnitine, and researchers found that the effects were the most profound in those subjects most challenged by “the blues” (Tempesta 1987).
Brain Tonic's all natural ingredients contribute to a better quality of life.
The manufacturer, distributers and marketers do not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. No claims or endorsements are made for any drugs or compounds currently marketed or in investigative use. This material is not intended as a guide to self-medication. The reader is advised to discuss the information provided here with a doctor, pharmacist, nurse, or other authorized healthcare practitioner and to check product information (including package inserts) regarding dosage, precautions, warnings, interactions, and contraindications before administering any drug, herb, or supplement discussed herein. Our products are manufactured in Johannesburg, South Africa, at a certified GMP laboratory. GMP stands for Good Manufacturing Practice. It is a recognised standard of quality for pharmaceutical and supplement manufacture and is enforced through regular governement inspections, controls and checks. COA certifies our ingredients. This stands for Certificate of Analysis and is a recognised world wide industry standard for quality of pharmaceutical and supplement ingredients.
© 2012 Smart Supplements
Site design by: